Journal article
Engineered Hydrogen-Bonded Glycopolymer Capsules and Their Interactions with Antigen Presenting Cells
K Kempe, SD Xiang, P Wilson, MA Rahim, Y Ju, MR Whittaker, DM Haddleton, M Plebanski, F Caruso, TP Davis
ACS Applied Materials and Interfaces | AMER CHEMICAL SOC | Published : 2017
Abstract
Hollow glycopolymer microcapsules were fabricated by hydrogen-bonded layer-by-layer (LbL) assembly, and their interactions with a set of antigen presenting cells (APCs), including dendritic cells (DCs), macrophages (MACs), and myeloid derived suppressor cells (MDSCs), were investigated. The glycopolymers were obtained by cascade postpolymerization modifications of poly(oligo(2-ethyl-2-oxazoline methacrylate)-stat-glycidyl methacrylate) involving the modification of the glycidyl groups with propargylamine and the subsequent attachment of mannose azide by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). Multilayer assembly of the hydrogen-bonding pair (glycopolymer/poly(methacrylic acid..
View full abstractRelated Projects (2)
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank Sylvia T. Gunawan and Ka Fung Noi for their help with the preparation of glycopolymer capsules. This work was carried out within the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). P.W. thanks the Leverhulme Trust for an Early Career Fellowship (ECF/2015-075). K.K. gratefully acknowledges the award of a NHMRC-ARC Dementia Research Development Fellowship (APP1109945). M.P. is a NHMRC Senior Research Fellow (APP1059409). F.C. (FL120100030) and T.P.D. (FL140100052) are grateful for the awards of Australian Laureate Fellowships from the ARC.